Blog Detail
In the Pipeline
http://pipeline.corante.com
A working medicinal chemist blogs about what it's like to try to discover drugs.
- Added on: Sep 18th, 2007
- Country: United States
- Language: English
Recent Posts
Manfred Christl Rides Again (Bonus Idiotic Lab Accident, Too)
Readers may remember the incident a couple of years ago where a paper was published claiming the synthesis of some very odd-looking 12-membered ring compounds. Prof. Manfred Christl of the University of Würzburg noticed something odd about this reac...
The Cost of New Drugs
I'm continuing my look at Bernard Munos' paper on the drug industry, which definitely repays further study (previous posts here, here, and here). Now for some talk about money - specifically, how much of it you'll need to find a new drug. The Munos p...
Another Take on the Munos Paper
Eric Milgram over at PharmaConduct has an excellent post up on the same paper I've been discussing this morning. As another guy who's been around the block a few times in this industry, he's struck by many of the same points I am (to the point of als...
Munos On Big Companies and Small Ones
So that roughly linear production of new drugs by Pfizer, as shown in yesterday's chart, is not an anomaly. As the Bernard Munos article I've been talking about says: Surprisingly, nothing that companies have done in the past 60 years has affected t...
Pfizer\'s R&D Productivity
Courtesy of Bernard Munos, author of the Nature Reviews article that I began blogging about yesterday, comes this note about Pfizer's track record with new molecules. His list of Pfizer NMEs since 2000 is Geodon (ziprasidone, 2001), Vfend (voriconazo...
Selective Scaffolds
We spend a lot of time in this business talking about molecular scaffolds - separate chemical cores that we elaborate into more advanced compounds. And there's no doubt that such things exist, but is part of the reason they exist just an outcome of t...
