Recent Posts Tagged With 'target'

• New Key Factor Identified in the Development of Alzheimers Disease

  Posted on Friday January 8th, 2010 at 07:26 in brain, target, cell biology, medical center, biomedical research

  Story Summary: However, a new study published online by Proceedings of the National Academy of Sciencesidentifies ssCTF, a small protein found in APP, as a novel factor for the development of Alzheimers disease related endosome abnormalities, which h...

• Using modern sequencing techniques to study ancient modern humans

  Posted on Saturday January 2nd, 2010 at 14:28 in animals, target, contamination, second generation, dead plants

  Story Summary: DNA that is left in the remains of long-dead plants, animals, or humans allows a direct look into the history of evolution. So far, studies of this kind on ancestral members of our own species have been hampered by scientists inability...

• Alnylam and Collaborators at MIT Report New Pre-clinical Research on Systemic Delivery of RNAi Therapeutics

  Posted on Friday January 1st, 2010 at 20:58 in collaboration, target, molecules, liver, delivery solutions

  Story Summary: (Nasdaq: ALNY), a leading RNAi therapeutics company, and collaborators from the David H. Koch Institute for Integrative Research at the Massachusetts Institute of Technology (MIT) today announced the publication of new data in the jou...

• Small Molecules Found To Protect Cells In Multiple Models Of ParkinsonaS Disease

  Posted on Friday January 1st, 2010 at 11:17 in target, hallmark, molecules, model systems, udall center

  Story Summary: Misfolded copies of the alpha-synuclein protein in brain cells are a hallmark of Parkinsons disease. In this research, we used yeast as a Parkinsons disease model system to identify the compounds that really work in two higher order mo...

• Small molecules found to protect cells in multiple models of Parkinsons disease

  Posted on Friday January 1st, 2010 at 00:23 in target, molecules, beneficial effect, yeasts, postdoctoral researcher

  Story Summary: And that shows that those compounds targets are highly conserved over a billion years of evolution. There is currently no cure for the disease, and current Parkinsons therapies only address disease symptoms, not the diseases cellular c...

• Compugen Discovers Drug Target for Treatment of Epithelial Tumors

  Posted on Thursday December 31st, 2009 at 16:23 in proteins, target, validation, product candidate, splice variants

  Story Summary: Furthermore, in these mRNA experiments, CGEN-671s expression level in various healthy tissues was up to 200 times lower than the expression level of the previously known cancer target CD55, suggesting that the Compugen discovered splic...

• Flowering powers genetic understanding

  Posted on Tuesday December 29th, 2009 at 07:10 in target, negative comments, arabidopsis, messenger rna, reproductive phase

  Story Summary: Until relatively recently genome sequencing projects, and studies of gene expression have mostly focussed on the messenger RNA transcripts produced from genes that contain the code needed to make proteins. But as well as this coding RN...

• A novel gene found for childhood-onset asthma

  Posted on Sunday December 27th, 2009 at 04:24 in target, molecules, allergens, cytokines, childhood onset

  Story Summary: Because the gene, called DENND1B, affects cells and signaling molecules thought to be instrumental in the immune system overreaction that occurs in asthma, the discovery may have singled out an important target for new treatments. It a...

• Stapled Peptides can open routes to new therapy approaches for multiple diseases

  Posted on Friday December 25th, 2009 at 10:14 in target, apoptosis, 22 years, growth factors, cytochrome c

  Story Summary: Programmed cell death or apoptosis is needed to destroy cells that are a threat to the integrity of the organism. In some cases it has been observed that apoptosis is not the main mechanism for the death of cancer cells in response to ...

• Mystery solved: Scientists now know how smallpox kills

  Posted on Thursday December 24th, 2009 at 17:39 in target, molecules, immunity, research associations, faseb j

  Story Summary: These studies demonstrate the production of an interferon binding protein by variola virus and monkeypox virus, and point at this viral anti-interferon protein as a target to develop new therapeutics and protect people from smallpox an...

• Researchers create new smart nanocapsule delivery system for use in protein therapy

  Posted on Saturday December 19th, 2009 at 14:46 in target, tang, skin layers, cellular imaging, protein core

  Story Summary: But its effectiveness has been limited by low delivery efficiency and the poor stability of proteins, which are frequently broken down and digested by cells protease enzymes before they reach their intended target. In what could signal...