"New York University professor Paul Vitz once observed, "Contemporary psychology is a form of secular humanism based on the rejection of God and the worship of the self." In her substitution of psychology for theology, Oprah Winfrey has become a high priestess and icon of the psychologization of American society. When she features prominent New Age figures on her television show, she helps to mainstream New Age influences and philosophies among millions of Americans. Her substitution of spirituality for biblical Christianity, her promotion of forgiveness without atonement, and her references to a god "without labels" puts her at the epicenter of a seismic cultural earthquake." (Taken from https://www.albertmohler.com/commentary_read.php?cdate=2005-11-29 )
God, who at sundry times and in divers manners spake in time past unto the fathers by the prophets, Hath in these last days spoken unto us by his Son, whom he hath appointed heir of all things, by whom also he made the worlds; Who being the brightness of his glory, and the express image of his person, and upholding all things by the word of his power, when he had by himself purged our sins, sat down on the right hand of the Majesty on high; Being made so much better than the angels, as he hath by inheritance obtained a more excellent name than they.
The Holy Bible : King James Version. (Heb 1:1-4).
2 Tim 4:3
For the time will come when they will not endure sound doctrine; but after their own lusts shall they heap to themselves teachers, having itching ears;

For many deceivers are entered into the world, who confess not that Jesus Christ is come in the flesh. This is a deceiver and an antichrist. Look to yourselves, that we lose not those things which we have wrought, but that we receive a full reward. Whosoever transgresseth, and abideth not in the doctrine of Christ, hath not God. He that abideth in the doctrine of Christ, he hath both the Father and the Son.
If there come any unto you, and bring not this doctrine, receive him not into your house, neither bid him God speed: For he that biddeth him God speed is partaker of his evil deeds.
The Holy Bible : King James Version. (2 Jn 7-11).

There is no Christ-less gospel! Anything that exalts itself above the name of Jesus or claims victory over sin without the blood of Jesus or declares true and ultimate freedom without Jesus' resurrection is simply a false doctrine! He is the Way, the Truth and the Life! Christ in you is the hope of glory!
God bless Oprah and give her the grace she needs to carry such a responsibility with fear and trembling as she ought! Let her fully understand the impact that she has on people and therefore use it for your Kingdom! Lead her not into temptation and deliver her from evil!

Grace and Peace,